Tigecycline 50 mg powder for solution for infusion.
Tigecycline, a glycylcycline antibiotic, inhibits protein translation in bacteria by binding to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules into the A site of the ribosome. This prevents incorporation of amino acid residues into elongating peptide chains. In general, tigecycline is considered bacteriostatic. At 4 times the minimum inhibitory concentration (MIC), a 2-log reduction in colony counts was observed with tigecycline against Enterococcus spp., Staphylococcus aureus, and Escherichia coli.
Tigecycline is indicated in adults and in children from the age of eight years for the treatment of the following infections:
-Complicated skin and soft tissue infections (cSSTI), excluding diabetic foot infections
-intra-abdominal infections (cIAI).
-Tigecycline should be used only in situations where other alternative antibiotics are not suitable.