Methylprednisolone Rompharm 250mg, 500mg and 1000 mg powder and solvent for solution for injection

Sodium salt of the succinate ester of methylprednisolone, is a synthetic steroid with a potent anti-inflammatory action superior to that of prednisolone and a lower tendency to sodium and water retention.

Methylprednisolone sodium succinate has the same metabolism and anti-inflammatory action of methylprednisolone. Administered parenterally in equimolar amounts, the two molecules demonstrate an equivalent biological activity. The relative potency of methylprednisolone sodium succinate and of hydrocortisone sodium succinate, as demonstrated by the decrease in eosinophyl counts after intravenous administration, is four to one.

Therapeutic indications

1.     Endocrine disorders

Acute adrenocortical insufficiency.

2.     Collagen diseases

During a flare-up or as maintenance therapy in particular cases of systemic lupus erythematosus.

3.     Dermatologic diseases

a. Pemphigus

b. Severe erythema multiforme (Stevens-Johnson syndrome)

c. Exfoliative dermatitis

4.     Allergic states

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in:

a.   Bronchial asthma

b.   Contact dermatitis

c.   Serum sickness

d.   Drug hypersensitivity reactions

e.   Angioneurotic oedema, urticaria, anaphylactic shock (in addition to epinephrine)

5.     Gastrointestinal diseases

Ulcerative colitis (systemic therapy or as retention or drip enema, to make the patient overcome a particularly critical stage of the disease), regional enteritis.

6.     Edematous states

To induce diuresis or remission of proteinuria in the idiopathic nephrotic syndrome without uremia, or nephrotic syndrome associated with lupus erythematosus.

7.     Nervous system

Cerebral edema from tumor – primary or metastatic and/or associated with surgical or radiation therapy, acute exacerbations of multiple sclerosis, acute spinal cord injury.

8.     Oncological diseases

For palliative management of: leukemias and lymphomas in adults, acute leukemia of childhood

Palliative therapy of advanced tumours.

Methylprednisolone Rompharm can also be used in the following conditions:

a.          Generalised neurodermatitis

b.          Acute rheumatic fever

c.          Severe shock: haemorrhagic, traumatic, surgical

d.          Prevention of nausea and vomiting associated with cancer chemotherapy

e.          Adjuvant therapy in severe Pneumocystis jiroveci pneumonia in subjects with AIDS.