Daptocycin

350 mg powder for solution for injection or infusion

500 mg powder for solution for injection or infusion.

Daptomycin is a cyclic lipopeptide natural product that is active against Gram positive bacteria only. The mechanism of action involves binding (in the presence of calcium ions) to bacterial membranes of both growing and stationary phase cells causing depolarisation and leading to a rapid inhibition of protein, DNA, and RNA synthesis. This results in bacterial cell death with negligible cell lysis.

Daptocycin is indicated for the treatment of the following infections:

-Adult and paediatric (1 to 17 years of age) patients with complicated skin and soft-tissue infections (cSSTI).

-Adult patients with right-sided infective endocarditis (RIE) due to Staphylococcus aureus. 

-Adult and paediatric (1 to 17 years of age) patients with Staphylococcus aureus bacteraemia (SAB).